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KMID : 1189420090220010001
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2009 Volume.22 No. 1 p.1 ~ p.10
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The Effects of Ethosome and Liposome Formulation Entrapped DL-HGF to Hair Growth Activity in Animal Model
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Kim Hyun-Woo
Jung Young-Joon
Lee Dong-Gye
Han Sang-Geun
Choung Eui-Su
Kim Hee-Taek
Kang Se-Chan
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Abstract
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Objectives : To investigate the effects of DL-HGF to hair growth activity in mouse, various kinds of ethosome and liposome formulations entrapped DL-HGF were produced and this study was carried out.
Methods : The B16/BL6 mice were classified into five groups: vehicle control (Con) group, Et-1-applied group, Et-2-applied group, LP-1-applied group, LP-2-applied group. Active hair growth (anagen) was induced in the back skin by application of a wax?osin mixture with subsequent depilation and the activity of hair growth was measured by macroscopic observation and histology.
Results : In vehicle control group, there was no hair growth activity during experiment period. In Et-1-applied group, the rate of hair growth was about 100%, LP-1-applied group and Et-2-applied group showed 70-80% and 40-50% of hair growth rates, respectively. The rate of hair growth of LP-2-applied group was lower than other applied groups (20-30%). In H/E staining, Numerous hair folicles and hair shafts were observed in Et-1-applied group and other groups showed lower level of hair folicles and hair shafts formation than Et-1-applied group.
Conclusion : Et-1 formulation showed highest hair growth activity than other ethosome and liposome formulations entrapped DL-HGF.
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KEYWORD
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Hair growth, DL-HGF, Ethosome, Liposome
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